Clinical Support

Tirosint® Supported by Clinical Practice Guidelines

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Use of Tirosint® is supported by clinical practice guidelines issued by prominent medical associations for the treatment of hypothyroidism in adults.

Co-Sponsored by the American Association of Clinical Endocrinology (AACE) and the American Thyroid Association (ATA)⁷
Insights from Clinical Practice Guidelines:
  • Current recommendations encourage the use of a consistent T4 preparation for individuals to minimize variability from refill to refill
  • Some reports have indicated an apparent increased dosage requirement for T4 in some patients with diminished gastric acid secretion
  • This led to in vitro work showing significant differences in dissolution among T4 preparations, profiles of which appear to be dependent on the pH of the solution in which the preparations were dissolved. The liquicap preparation (Tirosint®) was least affected by changes in pH.

The clinical significance of these findings remains unclear.

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